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    • Medical Devices
    • Bone Graft Substitutes
    • MedTech Services
    • Medical Grade Collagen
    • scCO2 Technology
    • Funding
    • Contact
    • News
  • Home
  • Medical Devices
  • Bone Graft Substitutes
  • MedTech Services
  • Medical Grade Collagen
  • scCO2 Technology
  • Funding
  • Contact
  • News

Medical Grade Collagen

Collagen is the most abundant protein in the human body and a key structural component of skin, bone, cartilage, tendons, ligaments, blood vessels, and other connective tissue. Collagen provides strength, elasticity, and structural support, and natural production decreases in the body after 30 years. Collagen Extracellular Matrix Proteins (ECMs) provide structural support and dynamic signaling cues that regulate cell behavior and tissue morphogenesis. Collagen provides mechanical integrity to biological tissues that sustains three-dimensional (3D) shape and stability. On the cellular side, collagen triggers mechano-transduction pathways that regulate cellular processes such as proliferation, differentiation, angiogenesis, and migration. Owing to the importance of collagen within biological tissues, disruption to collagen deposition and remodeling is associated with aging and disease. For these reasons, therapies that target collagen hold potential for regenerative medicine and tissue engineering. Collagen-based products are actively being used in clinical trials for various biomedical applications and tissue engineering. 



We understand the importance of ethical and sustainable practices in sourcing collagen. Our medical-grade collagen is primarily derived from carefully selected animal sources, including Bovine, Porcine, and Equine. These sources are chosen for their compatibility with human biology, making them ideal for medical applications. We adhere to strict ethical standards in sourcing these materials, ensuring that all animal-derived collagen is obtained responsibly and sustainably. This approach not only aligns with our commitment to ethical practices but also ensures the highest quality and safety of the collagen used in human bodies. By meticulously overseeing the sourcing and processing of animal collagen, we ensure that our products meet the rigorous standards required for medical use, while also respecting the well-being and sustainability of our animal sources.

  • Highly purified, controlled source and processing

  • Sterilized, biocompatible, traceable
  • Manufactured under ISO 13485 / GMP Regulations 
  • Manufactured according ASTM guide for collagen for Surgical implants and substrates for Tissue Engineered Medical Products (see pdf)


We are one of the leading CMO for Medical Grade Collagen  in EU

https://hcm-medical.com/technologies/collagen-production-at-hcm-medical/


Our Medical Grade Collagen is in the clinic as a wound care and dermal filler

https://www.nithya.it/en/home-en/


See our product in clinic

https://www.youtube.com/watch?v=ce_cuxWwlsk

Main collagen types

  • Type I: Skin, bone, tendon (≈90% of body collagen)
  • Type II: Cartilage (joints)
  • Type III: Skin, blood vessels, organs
  • Type IV: Basement membranes (cell support)
  • Type V: Hair, placenta, cell surfaces


Fibrillar collagen type 1consists of three alpha (α)-chains (type I collagen: two α1-chain and one α2-chain and type II collagen: three α1-chains) that self-assemble into a left-handed triple helix structure. Individual collagen triple helixes are termed tropocollagen. The triple helix chains are stabilized through cross-linkages at the telopeptide regions of adjacent collagen helixes. These cross-linked tropocollagen molecules comprise collagen fibrils.

Clinical Applications of Medical Grade Collagen

1. Wound Care & Regenerative Medicine

1. Wound Care & Regenerative Medicine

1. Wound Care & Regenerative Medicine

  • Wound dressings (sponges, sheets, gels, powders)
  • Burns and chronic ulcers (diabetic foot, pressure ulcers)
  • Hemostatic agents

2. Orthopedics & Trauma

1. Wound Care & Regenerative Medicine

1. Wound Care & Regenerative Medicine

  • Bone graft substitutes
  • Scaffolds for bone regeneration
  • Cartilage repair matrices
  • Tendon and ligament augmentation

3. Dental & Oral Surgery

1. Wound Care & Regenerative Medicine

4. Cardiovascular Applications

  • Guided Bone Regeneration (GBR)
  • Guided Tissue Regeneration (GTR)
  • Socket preservation
  • Periodontal defect repair

4. Cardiovascular Applications

5. Plastic, Reconstructive & Aesthetic Surgery

4. Cardiovascular Applications

  • Heart valve leaflets
  • Vascular graft coatings
  • Hemostatic patches

5. Plastic, Reconstructive & Aesthetic Surgery

5. Plastic, Reconstructive & Aesthetic Surgery

5. Plastic, Reconstructive & Aesthetic Surgery

  • Dermal fillers
  • Soft tissue augmentation
  • Skin regeneration matrices

6. Drug Delivery & Tissue Engineering

5. Plastic, Reconstructive & Aesthetic Surgery

5. Plastic, Reconstructive & Aesthetic Surgery

  • Controlled drug release systems
  • Cell culture scaffolds
  • 3D bioprinting matrices

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